The thesis deals with the principles of creating a special theory of administrative and legal regulation of information security, analyzing the process of its analogy with physical laws, analyzing the threats and dangers to interests and the whole informational safety, affecting the simulation process, define the principles of constructing and researching the models of information security of social systems . Our theory takes into account the fact that the advanced modeling and forecasting of the chosen model, as well as the creation of an ideal (final) goal, has a positive and a negative side. Focusing on providing basic features, sometimes insignificant and secondary, from the point of view of tasks, one can skip those features that are objectively significant.

©Stepanenko,R.,Konovalova,T.&Stepanenko,V.TheclosecontactofTLR2-positive macrophagesisobservedinthesubepithelialsiteswithpositivelycoloreddendriticcells ofepidermis,thereby,theexpressionofmarkerintheseareaswasobservedinepithelial cells across the whole width of the layer up to the horny layer. The mentioned structural peculiarities may testify to activation of macrophages by dendritic cells of epidermis, which bind and concentrate the corresponding ligands. The analogous changes were found at study of TLR4 expression. The significant amount of TLR4 – positive dendritic cells,whichhadconsiderablylargersizesandwerespreadwiththeirappendicesupto the horny layer, was found in epidermis even after performed treatment. Hereby rather intensive background cytoplasmic coloration of those cells was observed. It should be mentionedthatthecoloniesofmicroorganismswereobservedinthehornyscalesofthe skin.

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