© Stepanenko, R., Konovalova, T. & Stepanenko, V.The close contact of TLR2-positive macrophages is observed in the subepithelial sites with positively colored dendritic cells of epidermis, thereby, the expression of marker in these areas was observed in epithelial cells across the whole width of the layer up to the horny layer. The mentioned structural peculiarities may testify to activation of macrophages by dendritic cells of epidermis, which bind and concentrate the corresponding ligands. The analogous changes were found at study of TLR4 expression. The significant amount of TLR4 – positive dendritic cells, which had considerably larger sizes and were spread with their appendices up to the horny layer, was found in epidermis even after performed treatment. Hereby rather intensive background cytoplasmic coloration of those cells was observed. It should be mentioned that the colonies of microorganisms were observed in the horny scales of the skin.