© Stepanenko, R., Konovalova, T. & Stepanenko, V.The close contact of TLR2-positive macrophages is observed in the subepithelial sites with positively colored dendritic cells of epidermis, thereby, the expression of marker in these areas was observed in epithelial cells across the whole width of the layer up to the horny layer. The mentioned structural peculiarities may testify to activation of macrophages by dendritic cells of epidermis, which bind and concentrate the corresponding ligands. The analogous changes were found at study of TLR4 expression. The significant amount of TLR4 – positive dendritic cells, which had considerably larger sizes and were spread with their appendices up to the horny layer, was found in epidermis even after performed treatment. Hereby rather intensive background cytoplasmic coloration of those cells was observed. It should be mentioned that the colonies of microorganisms were observed in the horny scales of the skin.

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Aim of this thesis: 1. To find the differences between the high and low innovative individuals on certain psychological variables like Kirton Adaption - Innovation personality, self - confidence, Internal - External Locus of Control, Interpersonal Trust and Values (Theoretical, Economical, Aesthetic, Social, Religious and Political). 2. To find out the differences between the high and low innovative firms in respect of organizational, environmental and work culture variables. 3. To find out those personality variables which effectively discriminate the high innovative individuals from those of the low innovative individuals. The above objectives are rewritten in the context of the present study. 1. To find the difference between the principals of high and low innovative firms engaged in the manufacture of medicines on certain psychological variables like Kirton Adaption - Innovation personality, self - confidence, Internal - External Locus of Control, Interpersonal Trust and Value