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©Stepanenko,R.,Konovalova,T.&Stepanenko,V.TheclosecontactofTLR2-positive macrophagesisobservedinthesubepithelialsiteswithpositivelycoloreddendriticcells ofepidermis,thereby,theexpressionofmarkerintheseareaswasobservedinepithelial cells across the whole width of the layer up to the horny layer. The mentioned structural peculiarities may testify to activation of macrophages by dendritic cells of epidermis, which bind and concentrate the corresponding ligands. The analogous changes were found at study of TLR4 expression. The significant amount of TLR4 – positive dendritic cells,whichhadconsiderablylargersizesandwerespreadwiththeirappendicesupto the horny layer, was found in epidermis even after performed treatment. Hereby rather intensive background cytoplasmic coloration of those cells was observed. It should be mentionedthatthecoloniesofmicroorganismswereobservedinthehornyscalesofthe skin.